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Saturday, July 11, 2020 | History

1 edition of Mammalian cell transformation by chemical carcinogens found in the catalog.

Mammalian cell transformation by chemical carcinogens

Mammalian cell transformation by chemical carcinogens

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Published by SenatePress in Princeton Junction (N.J.) .
Written in English


Edition Notes

Statementedited by N. Mishra, V. Dunkel, M. Mehlman.
SeriesAdvances in modern environmental toxicology -- vol.1
ContributionsMishra, N., Dunkel, V., Mehlman, M.
ID Numbers
Open LibraryOL21817784M

  Growth Regulation and Carcinogenesis discusses topics such as growth factors, including stimulators and inhibitors of proliferation; networks in proliferation regulation; differentiation-inducing factors; origins of neoplasia and their relationship to growth control; genetic alterations in cellular regulatory machinery; extrachromosomal phenomena; non-genotoxic carcinogens; immortalization Author: Walter R. Paukovits. Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells. The process is characterized by changes at the cellular, genetic, and epigenetic levels and abnormal cell division is a physiological process that occurs in almost all tissues and under a variety of circumstances.

Cell, Tissue, and Organ Culture Charity Waymouth. Cann and Herzenberg, a, b) are among the tools making possible the study of the genetics of mammalian cell and neoplastic cell population (Merchant and Neel, ; Harris, In vitro cell transformation with . The major classes of chemical carcinogens and how they were discovered are described. A property shared by many of them is that they, or one or more of their metabolites, are electrophiles that can damage DNA in mammalian cells, leading to cellular responses including DNA repair, cytotoxicity, apoptosis, mutagenesis, and malignant : David H. Phillips.

Chemical carcinogens include carbon electrophiles, which attack DNA. Examples of carbon electrophiles are mustard gas, some alkenes, aflatoxin, and benzo[a]pyrene. Cooking and processing foods can produce carcinogens. Grilling or frying food, in particular, can produce carcinogens such as acrylamide (in french fries and potato chips) and polynuclear aromatic hydrocarbons (in grilled meat). Mouse and human DNA used as in vitro-labeled “high-complexity” probes revealed hybridization between specific herpesvirus DNA fragments on Southern transfers and repetitive sequences present at 10 3 to 10 5 copies per mammalian cell genome. Several different sites of major cell-virus sequence homology have been detected in both the herpes simplex virus type 1 and type 2 genomes, and these.


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Mammalian cell transformation by chemical carcinogens Download PDF EPUB FB2

Mammalian cell transformation by chemical carcinogens. Princeton Junction, N.J.: Senate Press, © (OCoLC) Document Type: Book: All Authors / Contributors: Nirmal Kumar Mishra; V C Dunkel; Myron A Mehlman.

Get this from a library. Mammalian cell transformation systems: applications in the study of multistage chemical carcinogenesis. [C J Boreiko; International Cancer Research Data Bank.; Cancer Information Dissemination and Analysis Center (CIDAC) for Carcinogenesis and Cancer Biology.;]. Mutagenesis and cell transformation of mammalian cells in culture by chemical carcinogens.

Huberman E. In the process of in vitro cell transformation, normal cells, which have an oriented pattern of growth and a limited life span in vitro and which are not tumorigenic, are converted into cells that have a hereditary random pattern of growth Cited by: The introduction of a polycyclic hydrocarbon such as benzo(a)pyrene (BP) into normal golden hamster embryo cell cultures results, in addition to cytot Cited by: Abstract.

Short-term tests for carcinogen identification are an increasingly valuable means for rapid detection of the carcinogenic potential of a substance and for studying the mechanism of carcinogenic action removed from the Mammalian cell transformation by chemical carcinogens book complex interactions that are present in vivo.A variety of mammalian cell culture systems exist in which morphologic transformation is a reliable indicator of Cited by: 2.

Bouck N, di Mayorca G. Somatic mutation as the basis for malignant transformation of BHK cells by chemical carcinogens. Nature. Dec 23; ()– Breitman ML, Tsui LC, Buchwald M, Siminovitch L.

Introduction and recovery of a selectable bacterial gene from the genome of mammalian cells. Mol Cell Biol. Aug; 2 (8)–Cited by: Heidelberger C () Mammalian cell transformation and mammalian mutagenesis in vitro.

J Environ Pathol Toxicol 3: 69–87 PubMed Google Scholar Heilbronn R, Schlehofer JR, Yalkinoglu AÖ, Zur Hausen H () Selective DNA-amplification induced by carcinogens (initiators): evidence for a role of proteases and DNA polymerase A.

Int J Cancer 36 Cited by: 1. P.K. Gupta, in Fundamentals of Toxicology, Mammalian Cell Transformation. Most cell transformation assays utilize fibroblast cultures derived from embryonic tissue. The original studies showed that cells from C3H mouse fibroblast cultures developed morphologic changes and changes in growth patterns when treated with carcinogens.

@article{osti_, title = {Cell transformation and mutability of different genetic loci in mammalian cells by metabolically activated carcinogenic polycylic hydrocarbons}, author = {Huberman, E.}, abstractNote = {Treatment of experimental animals with chemical carcinogens, including some polycyclic hydrocarbons, can result in the formation of malignant tumors.

The recent surge of interest in designing, validating, and implementing short-term tests for carcinogens has been spurred by the fairly convincing correlation be­ tween the carcinogenicity and mutagenicity of chemicals and physical agents and by the assumption that DNA alteration, mutations, and chromosome aberrations are somehow involved in neoplastic transformation.

Read this article to learn about cell transformation and general characteristics of transformed cells. The four aspects of Cell Transformation are: (1) Genetic Instability (2) Immortalization (3) Aberrant Growth Control and (4) Tumorigenicity.

Cell transformation due to changes in the genetic material, and cell cloning involving the production of a population single cell are described here. MISHRA, V. DUNKEL and M. MEHLMAN (EDITORS) Advances in Modern Environmental Toxicology, Vol. 1: Mammalian Cell Transformation by Chemical Carcinogens Senate Press, Princeton Junction, NJ, p p, $ This long-awaited book is a fairly comprehensive review of mammalian cell transformation, with 17 chapters written by some of the foremost authorities in the field.

There are. Chemical engineers are actively involved in harnessing the full potential of mammalian cells, especially with regard to process design and optimization. such as filtration in the kidneys or synthesis and chemical transformation in the liver, most are not actively dividing.

@article{osti_, title = {Chemical carcinogens. Second edition}, author = {Searle, C.E.}, abstractNote = {This book looks at the latest research in chemical carcinogenic agents. To gain an understanding these agents and their importance in identifying the occupational and environmental causes of cancer.

Cell transformation assays (CTAs) are in vitro carcinogenicity tests measuring morphological transformation of cells either as transformed colonies (SHE cells) or foci (C3H/10T1/2 and BALB/c 3T3.Mammalian cell transformation: mechanisms of carcinogenesis and assays for carcinogens / editors, J.

Carl Barrett, Raymond W. Tennant Raven Press New York Wikipedia Citation Please see Wikipedia's template documentation for further citation fields that may be required.

Chemical and drug industries FDA, EPA, NIH, other governmental groups University or research institute laboratories Mutagenesis assays Bacterial systems (Ames' test) Mammalian cell culture in vivo test systems (Drosophila, fish, rodents) Cell culture transformation assays Assays for DNA binding or damage, chromosome damage.

The mouse-C3HT-1/2 cell system was described and its utility as a means of detecting chemical carcinogens was evaluated. The properties of 10T-1/2 cells were discussed, including growth characteristics, in-vivo tumorigenicity of chemically transformed cells, and endogenous hydrocarbon metabolizing capacity.

All three cell transformation assays can detect genotoxic carcinogens and tumour promoters (40). The SHE assay can also detect aneugens (42). With regard to human carcinogenicity, the three assays. Abstract.

Cell transformation assays (CTAs) have long been proposed as in vitro methods for the identification of potential chemical carcinogens.

Despite showing good correlation with rodent bioassay data, concerns over the subjective nature of using morphological criteria for identifying transformed cells and a lack of understanding of the mechanistic basis of the assays has limited their Cited by:.

Methods for Evaluating Potential Carcinogens and Anticarcinogens Carcinogenic activity in rodents, following the oral administration of certain dyes, was first demonstrated in the early s. Since then, numerous experimental studies have been conducted to identify carcinogens in the diets of humans.Key words: cancer stages,carcinogenesis evaluation, chemical carcinogens, chemical carcinogenesis.

INTRODUCTION Public opinion considers cancer to be an increasingly threatening disease, affecting people of all ages. After cardiovascular diseases, it is the second cause of death amongst the global population (HuffWeisburgerFile Size: KB.Toxicity Tests with Mammalian Cell Cultures B.

EKWALL, V. SILANO, A. PAGANUZZI-STAMMATI AND F. ZUCCO INTRODUCTION Cell culture can be used to screen for toxicity both by estimation of the basal functions of the cell (i.e.

those processes common to all types of cells) or by tests on specialized cell functions (Ekwall, b).